Inflammaging: mechanisms and role in the cardiac and vasculature

Amir Ajoolabady; Domenico Pratico; Manlio Vinciguerra; Gregory Y H Lip; Claudio Franceschi; Jun Ren

doi:10.1016/j.tem.2023.03.005

Inflammaging: mechanisms and role in the cardiac and vasculature

Trends Endocrinol Metab. 2023 Jun;34(6):373-387. doi: 10.1016/j.tem.2023.03.005. Epub 2023 Apr 17.

Authors

Amir Ajoolabady¹, Domenico Pratico², Manlio Vinciguerra³, Gregory Y H Lip⁴, Claudio Franceschi⁵, Jun Ren⁶

Affiliations

¹ Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
² Alzheimer's Center at Temple, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
³ Liverpool Centre for Cardiovascular Science, Liverpool Johns Moore University, Liverpool, UK.
⁴ Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, UK; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. Electronic address: Gregory.Lip@liverpool.ac.uk.
⁵ Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Institute of Neurological Sciences of Bologna, Bologna, Italy; Department of Applied Mathematics and Laboratory of Systems Biology of Aging, Lobachevsky University, Nizhny Novgorod, Russia. Electronic address: claudio.franceschi@unibo.it.
⁶ Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA. Electronic address: jren_aldh2@outlook.com.

PMID: 37076375
DOI: 10.1016/j.tem.2023.03.005

Abstract

Aging triggers a wide range of cellular and molecular aberrations in the body, giving rise to inflammation and associated diseases. In particular, aging is associated with persistent low-grade inflammation even in absence of inflammatory stimuli, a phenomenon commonly referred to as 'inflammaging'. Accumulating evidence has revealed that inflammaging in vascular and cardiac tissues is associated with the emergence of pathological states such as atherosclerosis and hypertension. In this review we survey molecular and pathological mechanisms of inflammaging in vascular and cardiac aging to identify potential targets, natural therapeutic compounds, and other strategies to suppress inflammaging in the heart and vasculature, as well as in associated diseases such as atherosclerosis and hypertension.

Keywords: aging; arteries; cardiac; inflammaging; inflammation; vasculature.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aging
Atherosclerosis*
Humans
Hypertension*
Inflammation / pathology