Auf der Maur et al.1 identify neurofibromin 1 (NF1) loss as a mechanism of resistance to PI3K inhibitor in breast cancer cells. NF1 loss leads to enhanced glycolysis, which may be targeted with the antioxidant N-acetyl cysteine (NAC).
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.