Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures

Zhi-Hui Meng; Tian-Tian Sun; Guo-Zheng Zhao; Yu-Fei Yue; Qing-Hua Chang; Hua-Jie Zhu; Fei Cao

doi:10.1007/s42995-020-00072-w

Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures

Mar Life Sci Technol. 2020 Nov 24;3(1):44-61. doi: 10.1007/s42995-020-00072-w. eCollection 2021 Feb.

Authors

Zhi-Hui Meng¹, Tian-Tian Sun¹, Guo-Zheng Zhao¹, Yu-Fei Yue¹, Qing-Hua Chang¹, Hua-Jie Zhu¹, Fei Cao¹

Affiliation

¹ College of Pharmaceutical Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002 China.

Abstract

Marine-derived fungi are well known as rich sources of bioactive natural products. Growing evidences indicated that indole alkaloids, isolated from a variety of marine-derived fungi, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities, and therefore, indole alkaloids have potential to be pharmaceutical lead compounds. Systemic compilation of the relevant literature. In this review, we demonstrated a comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities, covering literatures published during 1982-2019.

Keywords: Bioactivity; Chemical diversity; Indole alkaloid; Marine-derived fungus.

Publication types

Review