SARS-CoV-2 main protease Nsp5 cleaves and inactivates human tRNA methyltransferase TRMT1

J Mol Cell Biol. 2023 Aug 3;15(4):mjad024. doi: 10.1093/jmcb/mjad024.

Authors

Jia-Li Lu¹, Xiao-Long Zhou^{1

2}

Affiliations

¹ State Key Laboratory of Molecular Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
² Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents
COVID-19*
Coronavirus 3C Proteases
Humans
SARS-CoV-2
Transcription Factors
tRNA Methyltransferases*

Substances

3C-like proteinase, SARS-CoV-2
Antiviral Agents
Coronavirus 3C Proteases
Transcription Factors
tRNA Methyltransferases
TRMT1 protein, human