New horizons of microphysiological systems: India forging its path in human-relevant research

Biol Open. 2023 Apr 15;12(4):bio059847. doi: 10.1242/bio.059847. Epub 2023 Apr 18.

Abstract

The past decade has seen expeditious developments in our ability to grow and maintain a variety of human cells and tissues, with properties closely mimicking those in the human body. Prominent researchers and entrepreneurs from all over the world assembled in Hyderabad, India to discuss developments in this field that have not only aided fundamental understanding of organ development and disease processes but have served as good physiological models for toxicity testing and drug development. The speakers presented ingenious, cutting-edge technology and forward-thinking ideas. This report presents the salient aspects of their discussions, highlights the importance of identifying unmet needs, and discusses setting of standards that will help regulatory approvals as we move into a new era, with nominal animal use in research and effective drug discovery.

Keywords: Microphysiological systems; Organ-on-chip; Organoid; Stem cell biology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Discovery
  • Humans
  • India
  • Lab-On-A-Chip Devices*
  • Microphysiological Systems*