Novel insights into the multifaceted roles of m6A-modified LncRNAs in cancers: biological functions and therapeutic applications

Jinxin Tang; Jinhui Zhang; Yu Lu; Jieyu He; Hua Wang; Binfeng Liu; Chao Tu; Zhihong Li

doi:10.1186/s40364-023-00484-7

Novel insights into the multifaceted roles of m⁶A-modified LncRNAs in cancers: biological functions and therapeutic applications

Biomark Res. 2023 Apr 17;11(1):42. doi: 10.1186/s40364-023-00484-7.

Authors

Jinxin Tang^{1

2

3}, Jinhui Zhang³, Yu Lu³, Jieyu He⁴, Hua Wang^{1

2

3}, Binfeng Liu^{1

2}, Chao Tu^{5

6}, Zhihong Li^{7

8}

Affiliations

¹ Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
² Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
³ Xiangya School of Medicine, Central South University, Changsha, Hunan, 410011, China.
⁴ Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
⁵ Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. tuchao@csu.edu.cn.
⁶ Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. tuchao@csu.edu.cn.
⁷ Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. lizhihong@csu.edu.cn.
⁸ Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. lizhihong@csu.edu.cn.

Abstract

N6-methyladenosine (m⁶A) is considered as the most common and important internal transcript modification in several diseases like type 2 diabetes, schizophrenia and especially cancer. As a main target of m⁶A methylation, long non-coding RNAs (lncRNAs) have been proved to regulate cellular processes at various levels, including epigenetic modification, transcriptional, post-transcriptional, translational and post-translational regulation. Recently, accumulating evidence suggests that m⁶A-modified lncRNAs greatly participate in the tumorigenesis of cancers. In this review, we systematically summarized the biogenesis of m⁶A-modified lncRNAs and the identified m⁶A-lncRNAs in a variety of cancers, as well as their potential diagnostic and therapeutic applications as biomarkers and therapeutic targets, hoping to shed light on the novel strategies for cancer treatment.

Keywords: Biomarker; Cancer; LncRNA; Sarcoma; m6A-modification.

Publication types

Review

Abstract

Publication types

Grants and funding