New secondary metabolites and volatile constituents from the leaves of Ocimum gratissimum Linn

Muhammad Shaiq Ali; Almas Hashmi; Ngoupayo Joseph

doi:10.1080/14786419.2023.2200943

New secondary metabolites and volatile constituents from the leaves of Ocimum gratissimum Linn

Nat Prod Res. 2023 Apr 17:1-7. doi: 10.1080/14786419.2023.2200943. Online ahead of print.

Authors

Muhammad Shaiq Ali¹, Almas Hashmi¹, Ngoupayo Joseph²

Affiliations

¹ H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
² Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine, University of Yaounde 1, Cameroon, Africa.

PMID: 37067231
DOI: 10.1080/14786419.2023.2200943

Abstract

The phytochemical investigation on the ethanolic extract of the leaves of Ocimum gratissimum (syn. O. viride) has led to the isolation of a new alkaloid, diazovirid or 1,1^'-(diazeno1,2-diyl) bis (ethane-1,2-diol) (1) and 2-hydroxy-D-glucal or (2 R, 3S, 4S)-2-(hydroxymethyl)-3,4-dihydro-2H-pyran-3,4,5-triol (2), reported for the first time as a natural product. Their structures were determined by spectroscopic analyses. The volatile constituents have also been studied by GC-FID and GC-MS leading to the characterization of compounds 3-18, respectively.

Keywords: 2-hydroxy glucal; GC; Lamiaceae; Ocimum gratissimum; alkaloid; volatile constituents.