Four new compounds isolated from the rhizomes of Phedimus aizoon (L.) 't Hart

Nat Prod Res. 2023 Apr 17:1-9. doi: 10.1080/14786419.2023.2198711. Online ahead of print.

Abstract

One new coumarin, one new flavonoid, two new distinctive compounds with characteristics of an iriflophene unit and a flavonoid unit connecting via a furan ring, together with five known compounds were isolated from the rhizomes of Phedimus aizoon (L.) 't Hart. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 4, 5 and 8 increased the survival rate of H9c2 cells induced by doxorubicin in vitro, which was capable of further drug exploration.

Keywords: Phedimus aizoon (L.) ‘t Hart; Sedumnin; coumarin; flavonoids; iriflophene.