Neuroendocrine pathogenesis of perimenopausal depression

Yuping Han; Simeng Gu; Yumeng Li; Xin Qian; Fushun Wang; Jason H Huang

doi:10.3389/fpsyt.2023.1162501

Neuroendocrine pathogenesis of perimenopausal depression

Front Psychiatry. 2023 Mar 30:14:1162501. doi: 10.3389/fpsyt.2023.1162501. eCollection 2023.

Authors

Yuping Han¹, Simeng Gu¹, Yumeng Li¹, Xin Qian¹, Fushun Wang², Jason H Huang^{3

4}

Affiliations

¹ Department of Psychology, Medical School, Jiangsu University, Zhenjiang, China.
² Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, Sichuan, China.
³ Department of Neurosurgery, Baylor Scott and White Health, Temple, TX, United States.
⁴ Department of Surgery, Texas A&M University, Temple, TX, United States.

Abstract

With the development of social economics and the increase of working pressure, more and more women are suffering from long-term serious stress and showing symptoms of perimenopausal depression (PMD). The incidence rate of PMD is increasing, and the physical and mental health are seriously affected. However, due to the lack of accurate knowledge of pathophysiology, its diagnosis and treatment cannot be accurately executed. By consulting the relevant literature in recent years, this paper elaborates the neuroendocrine mechanism of perimenopausal depression from the aspects of epigenetic changes, monoamine neurotransmitter and receptor hypothesis, glial cell-induced neuroinflammation, estrogen receptor, interaction between HPA axis and HPG axis, and micro-organism-brain gut axis. The purpose is to probe into new ways of treatment of PMD by providing new knowledge about the neuroendocrine mechanism and treatment of PMD.

Keywords: MDD; PMD; emotion; life stress; neuroendocrine; perimenopausal depression; therapy; three primary color.

Publication types

Review