Recent advances of long non-coding RNAs in control of hepatic gluconeogenesis

Front Endocrinol (Lausanne). 2023 Mar 31:14:1167592. doi: 10.3389/fendo.2023.1167592. eCollection 2023.

Abstract

Gluconeogenesis is the main process for endogenous glucose production during prolonged fasting, or certain pathological conditions, which occurs primarily in the liver. Hepatic gluconeogenesis is a biochemical process that is finely controlled by hormones such as insulin and glucagon, and it is of great importance for maintaining normal physiological blood glucose levels. Dysregulated gluconeogenesis induced by obesity is often associated with hyperglycemia, hyperinsulinemia, and type 2 diabetes (T2D). Long noncoding RNAs (lncRNAs) are involved in various cellular events, from gene transcription to protein translation, stability, and function. In recent years, a growing number of evidences has shown that lncRNAs play a key role in hepatic gluconeogenesis and thereby, affect the pathogenesis of T2D. Here we summarized the recent progress in lncRNAs and hepatic gluconeogenesis.

Keywords: G6Pase; PEPCK; blood glucose; hepatic gluconeogenesis; long non-coding RNAs; type 2 diabetes.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diabetes Mellitus, Type 2* / genetics
  • Diabetes Mellitus, Type 2* / metabolism
  • Gluconeogenesis / genetics
  • Glucose / metabolism
  • Humans
  • Liver / metabolism
  • RNA, Long Noncoding* / genetics
  • RNA, Long Noncoding* / metabolism

Substances

  • RNA, Long Noncoding
  • Glucose

Grants and funding

This work was supported by the National Key Research and Development Program of China (Grant No. 2017YFA0701304), the National Natural Science Foundation of China (Nos. 81970747; 32271193), and the Scientific Program of Changshu City (csws202009).