The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review

Changchao Dong; Gang Tan; Guangyan Zhang; Wei Lin; Guanglin Wang

doi:10.3389/fbioe.2023.1133995

The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review

Front Bioeng Biotechnol. 2023 Mar 29:11:1133995. doi: 10.3389/fbioe.2023.1133995. eCollection 2023.

Authors

Changchao Dong^{1

2}, Gang Tan², Guangyan Zhang³, Wei Lin⁴, Guanglin Wang^{1

5}

Affiliations

¹ Trauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
² Department of Orthopedics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
³ Department of Respiratory Medicine, The 7th Hospital of Chengdu, Chengdu, Sichuan, China.
⁴ Department of Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.
⁵ Department of Orthopedics, West China Hospital, Orthopedics Research Institute, Sichuan University, Chengdu, Sichuan, China.

Abstract

The process of bone regeneration involves the interaction of the skeletal, blood, and immune systems. Bone provides a solid barrier for the origin and development of immune cells in the bone marrow. At the same time, immune cells secrete related factors to feedback on the remodeling of the skeletal system. Pathological or traumatic injury of bone tissue involves changes in blood supply, cell behavior, and cytokine expression. Immune cells and their factors play an essential role in repairing foreign bodies in bone injury or implantation of biomaterials, the clearance of dead cells, and the regeneration of bone tissue. This article reviews the bone regeneration application of the bone tissue repair microenvironment in bone cells and immune cells in the bone marrow and the interaction of materials and immune cells.

Keywords: BMSCs; biomaterials; bone regeneration; immune cells; interaction.

Publication types

Review