Analysis of Characteristics, Pathogens and Drug Resistance of Urinary Tract Infection Associated with Long-Term Indwelling Double-J Stent

Yuehua Li; Li Jiang; Shengjun Luo; Daixing Hu; Xin Zhao; Guozhi Zhao; Wei Tang; Yu Guo

doi:10.2147/IDR.S392857

Analysis of Characteristics, Pathogens and Drug Resistance of Urinary Tract Infection Associated with Long-Term Indwelling Double-J Stent

Infect Drug Resist. 2023 Apr 8:16:2089-2096. doi: 10.2147/IDR.S392857. eCollection 2023.

Authors

Yuehua Li¹, Li Jiang², Shengjun Luo², Daixing Hu², Xin Zhao², Guozhi Zhao², Wei Tang², Yu Guo³

Affiliations

¹ Department of Urology, University-Town Hospital of Chongqing Medical University, Chongqing, 400000, People's Republic of China.
² Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400000, People's Republic of China.
³ Department of Urology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400000, People's Republic of China.

Abstract

Objective: To investigate the characteristics, pathogens and drug resistance of urinary tract infection (UTI) associated with long-term indwelling double-J stent.

Methods: The clinical data of 102 patients with urinary tract infection associated with long-term indwelling double-J stent in University-Town Hospital of Chongqing Medical University and Chongqing Traditional Chinese Medicine Hospital from September 2010 to July 2022 were collected retrospectively, and the difference between etiological characteristics were analyzed. Urine and double-J stent samples of patients were collected for pathogen identification and drug sensitivity test.

Results: A total of 102 patients, 39 (38.23%) males and 63 (61.77%) females, aged 24-72 years, with a median age of 48 years, were included in this study. Urinary calculi (40.20%) and ureteral stricture (24.50%) were the main causes of urinary tract infection associated with long-term indwelling double-J stent. Among the patients with urinary tract infection caused by double-J stent, female patients were higher than male patients (61.77% vs 38.23%). In terms of positive rate of pathogenic bacteria culture, the rate of double-J stent was higher than that of urine (67.65% vs 35.29%). The main pathogenic bacteria in urine were Escherichia coli (30.55%) of Gram negative bacteria, while the main pathogenic bacteria in double-J stent were enterococcus faecalis (27.53%) of Gram positive bacteria. The resistance rate of Gram positive bacteria in double-J stent to vancomycin, ciprofloxacin, meropenem and piperacillin/tazobactam was significantly higher than that in urine (P<0.05). The resistance rate of Gram negative bacteria in double-J stent to imipenem, cefepime, piperacillin/tazobactam, meropenem and cefoperazone/sulbactam was significantly higher than that in urine (P<0.05).

Conclusion: Double-J stent associated urinary tract infection is more common in women than in men. Escherichia coli and Enterococcus faecalis are the main pathogens, and the pathogens show strong drug resistance.

Keywords: biofilm; double-J stent; drug resistance; drug resistant bacteria; infection; pathogens; urinary tract infection.

Grants and funding

This work was supported by Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau), Fund No. 2023MSXM158.