Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease

Yinlan Wu; Yanhong Li; Yubin Luo; Yu Zhou; Xiuping Liang; Lu Cheng; Tong Wu; Ji Wen; Chunyu Tan; Yi Liu

doi:10.3389/fimmu.2023.1146904

Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease

Front Immunol. 2023 Mar 29:14:1146904. doi: 10.3389/fimmu.2023.1146904. eCollection 2023.

Authors

Yinlan Wu^{1

2

3}, Yanhong Li^{1

2

3}, Yubin Luo^{1

2

3}, Yu Zhou⁴, Xiuping Liang^{1

2

3}, Lu Cheng^{1

2

3}, Tong Wu^{1

2

3}, Ji Wen^{1

2

3}, Chunyu Tan^{1

2

3}, Yi Liu^{1

2

3}

Affiliations

¹ Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.
² Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
³ Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Chengdu, China.
⁴ Department of Respiratory and Critical Care Medicine, Chengdu First People's Hospital, Chengdu, China.

Abstract

Interstitial lung disease (ILD) is one of the most serious lung complications of connective tissue disease (CTD). The application of proteomics in the past decade has revealed that various proteins are involved in the pathogenesis of each subtype of CTD-ILD through different pathways, providing novel ideas to study pathological mechanisms and clinical biomarkers. On this basis, a multidimensional diagnosis or prediction model is established. This paper reviews the results of proteomic detection of different subtypes of CTD-ILD and discusses the role of some differentially expressed proteins in the development of pulmonary fibrosis and their potential clinical applications.

Keywords: connective tissue diseases-interstitial lung disease; differentially expressed proteins; idiopathic inflammatory myopathies; interstitial lung disease; proteomics; rheumatoid arthritis; systemic sclerosis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Connective Tissue Diseases* / diagnosis
Humans
Lung Diseases, Interstitial* / diagnosis
Prognosis
Proteomics

Substances

Biomarkers

Grants and funding

This work was supported by the National Natural Science Foundation of China (82001728 and 81973540), 1·3·5 project for Outstanding interdisciplinary project of West China Hospital, Sichuan University (ZYGD18015, ZYJC18003, and ZYJC18024), Sichuan Science and Technology Program (20YYJC3358), and from zero to one Innovative Research Program of Sichuan University (2022SCUH0020).