Emerging insights into the role of ferroptosis in the pathogenesis of autoimmune diseases

Junyu Fan; Ting Jiang; Dongyi He

doi:10.3389/fimmu.2023.1120519

Emerging insights into the role of ferroptosis in the pathogenesis of autoimmune diseases

Front Immunol. 2023 Mar 30:14:1120519. doi: 10.3389/fimmu.2023.1120519. eCollection 2023.

Authors

Junyu Fan^{1

2}, Ting Jiang^{1

2}, Dongyi He^{1

2

3}

Affiliations

¹ Department of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² Department of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China.
³ Institute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.

Abstract

Ferroptosis, a novel type of regulated cell death mediated by iron-dependent lipid oxidation, was discovered a decade ago. Significant progress has been made in our knowledge of ferroptosis and immune dysfunction. This review covers recent advancements in the interaction of ferroptosis and the immune system, with an emphasis on autoimmune diseases. The critical regulators of ferroptosis are summarized in the context of reactive oxygen species biology, lipid metabolism, and iron homeostasis. The molecular crosstalk between ferroptosis and different immune cells is also highlighted. Future research is expected to yield new insights into the mechanisms governing ferroptosis and its potential therapeutic benefits in autoimmune diseases.

Keywords: autoimmune diseases; ferroptosis; immunity; iron homeostasis; lipid metabolism; reactive oxygen species biology.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autoimmune Diseases* / etiology
Ferroptosis*
Homeostasis
Humans
Iron / metabolism
Reactive Oxygen Species / metabolism

Substances

Iron
Reactive Oxygen Species

Grants and funding

This work was supported by the National Nature Science Foundation of China (82104634) and the Clinical Research Project of Shanghai Municipal Health Commission (20214Y0165).