Associations between diet and incidence risk of lung cancer: A Mendelian randomization study

Haihao Yan; Xiao Jin; Changwen Zhang; Changjun Zhu; Yucong He; Xingran Du; Ganzhu Feng

doi:10.3389/fnut.2023.1149317

Associations between diet and incidence risk of lung cancer: A Mendelian randomization study

Front Nutr. 2023 Mar 31:10:1149317. doi: 10.3389/fnut.2023.1149317. eCollection 2023.

Authors

Haihao Yan¹, Xiao Jin¹, Changwen Zhang¹, Changjun Zhu¹, Yucong He¹, Xingran Du², Ganzhu Feng¹

Affiliations

¹ Department of Respiratory Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
² Department of Infectious Disease, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Abstract

Background: Observational studies have revealed associations between diet and lung cancer. However, it is unclear whether the association is disturbed by confounding factors. We used a two-sample Mendelian randomization (MR) method to characterize the associations between diet and the lung cancer risk (including 3 subtypes: lung adenocarcinoma (LA), squamous cell lung carcinoma (SqCLC), and small cell lung cancer (SCLC)).

Materials and methods: Data on 20 diets were screened from the UK Biobank. Lung cancer data came from a large meta-analysis of 85,716 individuals. The inverse-variance weighted method was used as the main analysis. Sensitivity analysis was also used to explain the different multiplicity patterns of the final model.

Results: Our results showed significant evidence that 3 diets were associated with lung cancer [odds ratio (OR): 0.271, 95% confidence interval (CI): 0.150-0.488, p = 1.46 × 10^-4, dried fruit; OR: 3.010, 95% CI: 1.608-5.632, p = 5.70 × 10^-4, beer] and SqCLC (OR: 0.135, 95% CI: 0.062-0.293, p = 2.33 × 10^-5, dried fruit; OR: 0.485, 95% CI: 0.328-0.717, p = 2.9 × 10^-4, cheese). There were also suggestive correlations between 5 dietary intakes and lung cancer (OR: 0.441, 95% CI: 0.250-0.778, p = 0.008, cereal; OR: 2.267, 95% CI: 1.126-4.564, p = 0.022, beef), LA (OR: 0.494, 95% CI: 0.285-0.858, p = 0.012, dried fruit; OR: 3.536, 95% CI: 1.546-8.085, p = 0.003, beer) and SCLC (OR: 0.006, 95% CI: 0.000-0.222, p = 0.039, non-oily fish; OR: 0.239, 95% CI: 0.086-0.664, p = 0.006, dried fruit). No other association between diet and lung cancer was observed.

Conclusion: Our study preliminary found that cheese, dried fruit, and beer intake were significantly associated with the risk of lung cancer or its subtypes, while cereal, beef, and non-oily fish intake were suggestively associated with the risk of lung cancer or its subtypes. Well-designed prospective studies are still needed to confirm our findings in the future.

Keywords: Mendelian randomization; diet; dietary intake; incidence risk; lung cancer.