Boron uptake of boronophenylalanine and the effect of boron neutron capture therapy in cervical cancer cells

Shinichi Terada; Satoshi Tsunetoh; Yoshimichi Tanaka; Tomohito Tanaka; Hideki Kashiwagi; Takushi Takata; Shinji Kawabata; Minoru Suzuki; Masahide Ohmichi

doi:10.1016/j.apradiso.2023.110792

Boron uptake of boronophenylalanine and the effect of boron neutron capture therapy in cervical cancer cells

Appl Radiat Isot. 2023 Jul:197:110792. doi: 10.1016/j.apradiso.2023.110792. Epub 2023 Apr 3.

Authors

Shinichi Terada¹, Satoshi Tsunetoh², Yoshimichi Tanaka², Tomohito Tanaka², Hideki Kashiwagi³, Takushi Takata⁴, Shinji Kawabata³, Minoru Suzuki⁴, Masahide Ohmichi²

Affiliations

¹ Department of Obstetrics and Gynecology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan. Electronic address: shinichi.terada@ompu.ac.jp.
² Department of Obstetrics and Gynecology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
³ Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
⁴ Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asasiro-Nishi, Kumatori-cho, Japan.

PMID: 37062147
DOI: 10.1016/j.apradiso.2023.110792

Abstract

There are few studies about boron neutron capture therapy (BNCT) for cervical cancer. The present study evaluated the biodistribution of boronophenylalanine (BPA) and the effect of BNCT on cervical cancer cell lines. BPA exposure and neutron irradiation of cervical cancer cell lines resulted in decreased survival fraction compared to irradiation only. In vivo cervical cancer tumor boron concentration was highest at 2.5 h after BPA intraperitoneal administration, and higher than in the other organs. BNCT may be effective against cervical carcinoma.

Keywords: Boron concentration; Cervical cancer; Neutron capture therapy.

MeSH terms

Boron / therapeutic use
Boron Compounds / therapeutic use
Boron Neutron Capture Therapy* / methods
Female
Humans
Tissue Distribution
Uterine Cervical Neoplasms* / radiotherapy

Substances

Boron
Boron Compounds