The relationship between CD4+ T cell glycolysis and their functions

Siyi Liu; Shan Liao; Lin Liang; Jun Deng; Yanhong Zhou

doi:10.1016/j.tem.2023.03.006

The relationship between CD4⁺ T cell glycolysis and their functions

Trends Endocrinol Metab. 2023 Jun;34(6):345-360. doi: 10.1016/j.tem.2023.03.006. Epub 2023 Apr 14.

Authors

Siyi Liu¹, Shan Liao², Lin Liang¹, Jun Deng³, Yanhong Zhou⁴

Affiliations

¹ NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China; Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.
² Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
³ Department of Early Clinical Trial Center, Hunan Cancer Hospital, Affiliated Tumor Hospital of Xiangya Medical School of Central South University, Changsha, Hunan 410013, China. Electronic address: dengjun@hnca.org.cn.
⁴ NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China; Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China. Electronic address: zhouyanhong@csu.edu.cn.

PMID: 37061430
DOI: 10.1016/j.tem.2023.03.006

Abstract

CD4⁺ T cells are effector T cells (Teffs) produced by the differentiation of initial T cells in peripheral lymphoid tissue after being attacked by antigens, and have an indispensable role in the development and activation of B cells and CD8⁺ T cells to regulate and assist immunity. In this review, we provide a new perspective on the relationship between CD4⁺ T cell glycolysis and its function. We summarize the effects of changes in the glycolysis level of CD4⁺ T cells on their activation, differentiation, proliferation, and survival. In addition, we emphasize that regulation of the glycolysis level of CD4⁺ T cells changes their inflammatory phenotypes and function. The study of immune metabolism has received more attention recently, but more work is needed to answer many open questions.

Keywords: CD4(+) T cell; differentiation; function; glycolysis; proliferation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes* / metabolism
Cell Differentiation
Glycolysis
Humans
Lymphocyte Activation*