The management of oligometastatic disease in colorectal cancer: Present strategies and future perspectives

Catia Carconi; Micaela Cerreti; Michela Roberto; Giulia Arrivi; Giancarlo D'Ambrosio; Francesca De Felice; Mattia Alberto Di Civita; Franco Iafrate; Pierleone Lucatelli; Fabio Massimo Magliocca; Andrea Picchetto; Vincenzo Picone; Carlo Catalano; Enrico Cortesi; Vincenzo Tombolini; Federica Mazzuca; Silverio Tomao

doi:10.1016/j.critrevonc.2023.103990

The management of oligometastatic disease in colorectal cancer: Present strategies and future perspectives

Crit Rev Oncol Hematol. 2023 Jun:186:103990. doi: 10.1016/j.critrevonc.2023.103990. Epub 2023 Apr 13.

Authors

Catia Carconi¹, Micaela Cerreti¹, Michela Roberto², Giulia Arrivi³, Giancarlo D'Ambrosio⁴, Francesca De Felice⁵, Mattia Alberto Di Civita⁶, Franco Iafrate⁷, Pierleone Lucatelli⁸, Fabio Massimo Magliocca⁷, Andrea Picchetto⁹, Vincenzo Picone¹⁰, Carlo Catalano⁸, Enrico Cortesi¹⁰, Vincenzo Tombolini⁵, Federica Mazzuca³, Silverio Tomao⁶

Affiliations

¹ Sant'Andrea University Hospital, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
² UOC Oncologia A, Department of radiological, Oncological and Anathomo-patological Science, Policlinico Umberto I, "Sapienza" University of Rome, 00161 Rome, Italy. Electronic address: mikiroberto87@gmail.com.
³ Oncology Unit, Sant' Andrea University Hospital, Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
⁴ Department of General Surgery, Surgical Specialties and Organ Transplantation, Policlinico Umberto I, "Sapienza" University of Rome, 00161 Rome, Italy.
⁵ Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
⁶ UOC Oncologia A, Department of radiological, Oncological and Anathomo-patological Science, Policlinico Umberto I, "Sapienza" University of Rome, 00161 Rome, Italy.
⁷ Department of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
⁸ Vascular and Interventional radiology Unit, Department of radiological, Oncological and Anathomo-patological Science, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
⁹ Emergency Department, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
¹⁰ UOC Oncologia B, Department of radiological, Oncological and Anathomo-patological Science, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.

PMID: 37061075
DOI: 10.1016/j.critrevonc.2023.103990

Abstract

Oligometastatic disease has been described as an intermediate clinical state between localized cancer and systemically metastasized disease. Recent clinical studies have shown prolonged survival when aggressive locoregional approaches are added to systemic therapies in patients with oligometastases. The aim of this review is to outline the newest options to treat oligometastatic colorectal cancer (CRC), also considering its molecular patterns. We present an overview of the available local treatment strategies, including surgical procedures, stereotactic body radiation therapy (SBRT), thermal ablation, as well as trans-arterial chemoembolization (TACE) and selective internal radiotherapy (SIRT). Moreover, since imaging methods provide crucial information for the early diagnosis and management of oligometastatic CRC, we discuss the role of modern radiologic techniques in selecting patients that are amenable to potentially curative locoregional treatments.

Keywords: Colorectal cancer (CRC); Oligometastatic disease (OMD); Radiofrequency ablation (RFA); Selective internal radiotherapy (SIRT); Stereotactic body radiation therapy (SBRT); Trans-arterial chemoembolization (TACE).

Publication types

Review

MeSH terms

Brachytherapy*
Colorectal Neoplasms* / diagnosis
Colorectal Neoplasms* / pathology
Colorectal Neoplasms* / therapy
Humans
Radiosurgery* / methods