Aperiodic subthalamic activity predicts motor severity and stimulation response in Parkinson disease

Darren L Clark; Talha Khalil; Linda H Kim; M Sohail Noor; Feng Luo; Zelma Ht Kiss

doi:10.1016/j.parkreldis.2023.105397

Aperiodic subthalamic activity predicts motor severity and stimulation response in Parkinson disease

Parkinsonism Relat Disord. 2023 May:110:105397. doi: 10.1016/j.parkreldis.2023.105397. Epub 2023 Apr 7.

Authors

Darren L Clark¹, Talha Khalil², Linda H Kim², M Sohail Noor², Feng Luo², Zelma Ht Kiss³

Affiliations

¹ Department of Clinical Neuroscience, Calgary, AB, Canada; Department of Psychiatry, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
² Department of Clinical Neuroscience, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
³ Department of Clinical Neuroscience, Calgary, AB, Canada; Department of Psychiatry, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. Electronic address: zkiss@ucalgary.ca.

PMID: 37060621
DOI: 10.1016/j.parkreldis.2023.105397

Abstract

Introduction: Rhythmic beta activity in the subthalamic nucleus (STN) local field potential (LFP) is associated with Parkinson disease (PD) severity, though not all studies have found this relationship. We investigated whether aperiodic 'noise' elements of LFP, specifically slope of the 1/f broadband, predict PD motor symptoms and outcomes of STN-DBS.

Methods: We studied micro-LFP from 19 PD patients undergoing STN-DBS, relating the aperiodic 1/f slope and the periodic beta oscillation components to motor severity using the UPDRS-III and improvement with DBS at 1 year.

Results: Beta power, not 1/f slope, independently predicted baseline UPDRS-III (r = 0.425, p = 0.020; r = -0.434, p = 0.032, respectively), but multiple regression using both predicted better (F (2, 16) = 6.621, p = 0.008, R² = 0.453). Only multiple regression using both slope and beta power predicted improvement in UPDRS-III at 1 year post-operatively (F (2, 15) = 6.049, R² = 0.446, p = 0.012).

Conclusions: Both beta synchronization and slope of the 1/f broadband are informative of motor symptoms in PD and predict response to STN-DBS.

Keywords: Deep brain stimulation; LFP; Parkinson disease; Subthalamic nucleus; aperiodic 1/f activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Deep Brain Stimulation*
Humans
Parkinson Disease* / complications
Parkinson Disease* / therapy
Subthalamic Nucleus* / physiology
Treatment Outcome