Accelerating the understanding of cancer biology through the lens of genomics

Dongfang Wang; Baolin Liu; Zemin Zhang

doi:10.1016/j.cell.2023.02.015

Accelerating the understanding of cancer biology through the lens of genomics

Cell. 2023 Apr 13;186(8):1755-1771. doi: 10.1016/j.cell.2023.02.015.

Authors

Dongfang Wang¹, Baolin Liu¹, Zemin Zhang²

Affiliations

¹ Biomedical Pioneering Innovative Center and School of Life Sciences, Peking University, Beijing 100871, China.
² Biomedical Pioneering Innovative Center and School of Life Sciences, Peking University, Beijing 100871, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; Changping Laboratory, Beijing, China. Electronic address: zemin@pku.edu.cn.

PMID: 37059071
DOI: 10.1016/j.cell.2023.02.015

Abstract

A core mission of cancer genomics is to comprehensively chart molecular underpinnings of cancer-driving events and to provide personalized therapeutic strategies. Primarily focused on cancer cells, cancer genomics studies have successfully uncovered many drivers for major cancer types. Since the emergence of cancer immune evasion as a critical cancer hallmark, the paradigm has been elevated to the holistic tumor ecosystem, with distinct cellular components and their functional states elucidated. We highlight the milestones of cancer genomics, depict the evolving path of the field, and discuss future directions in completing the understanding of the tumor ecosystem and in advancing therapeutic strategies.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Genomics
Humans
Neoplasms* / genetics
Neoplasms* / therapy
Precision Medicine