Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy

Long Bai; Yanpeng Liu; Xiaohui Zhang; Peiru Chen; Ruiqiang Hang; Yin Xiao; Jing Wang; Changsheng Liu

doi:10.1016/j.biomaterials.2023.122125

Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy

Biomaterials. 2023 Jun:297:122125. doi: 10.1016/j.biomaterials.2023.122125. Epub 2023 Apr 10.

Authors

Long Bai¹, Yanpeng Liu², Xiaohui Zhang², Peiru Chen³, Ruiqiang Hang⁴, Yin Xiao⁵, Jing Wang⁶, Changsheng Liu⁷

Affiliations

¹ Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200237, China.
² Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China; The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200237, China.
³ State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Institute of Lifeomics, Beijing, 102206, China.
⁴ Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
⁵ School of Medicine and Dentistry, Griffith University, Gold Coast, Australia; Australia-China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, Brisbane, Australia. Electronic address: yin.xiao@qut.edu.au.
⁶ Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China; The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200237, China. Electronic address: wangjing08@ecust.edu.cn.
⁷ Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China; The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200237, China. Electronic address: liucs@ecust.edu.cn.

PMID: 37058900
DOI: 10.1016/j.biomaterials.2023.122125

Abstract

The pace of bone formation slows down with aging, which leads to the development of osteoporosis. In addition to senescent bone marrow mesenchymal stem cells (S-BMSCs), senescent macrophages (S-MΦs) present in the bone marrow produce numerous inflammatory cytokines that contribute to the inflammaged microenvironment and are involved in the development of osteoporosis. Although autophagy activation has shown a significant anti-aging effect, its influence on inflammaging and its role in osteoporosis treatment remain unclear. Traditional Chinese herbal medicine contains bioactive components that exhibit remarkable advantages in bone regeneration. We have demonstrated that icariin (ICA), a bioactive component of traditional Chinese herbal medicine, activates autophagy, exerts a significant anti-inflammaging effect on S-MΦs, and rejuvenates osteogenesis of S-BMSCs, thereby alleviating bone loss in osteoporotic mice. The transcriptomic analysis further reveals that the TNF-α signaling pathway, which is significantly associated with the level of autophagy, regulates this effect. Moreover, the expression of senescence-associated secretory phenotype (SASP) is significantly reduced after ICA treatment. In summary, our findings suggest that bioactive components/materials targeting autophagy can effectively modulate the inflammaging of S-MΦs, offering an innovative treatment strategy for osteoporosis remission and various age-related comorbidities.

Keywords: Autophagy; Icariin; Inflammaging; Macrophage; Osteoporosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autophagy
Cell Differentiation
Drugs, Chinese Herbal* / pharmacology
Drugs, Chinese Herbal* / therapeutic use
Flavonoids / pharmacology
Flavonoids / therapeutic use
Mice
Osteogenesis / genetics
Osteoporosis* / drug therapy
Osteoporosis* / metabolism

Substances

icariin
Drugs, Chinese Herbal
Flavonoids