The enhanced visible light driven photocatalytic activity of zinc porphyrin/g-C3N4 nanosheet for efficient bacterial infected wound healing

Hao Cheng; Niuniu Wang; Yongqiang Yang; Xiong Jiao; Peide Han; Wangping Duan; Di Huang; Meiwen An; Weiyi Chen; Xiaohong Yao; Xiangyu Zhang

doi:10.1016/j.jcis.2023.04.002

The enhanced visible light driven photocatalytic activity of zinc porphyrin/g-C₃N₄ nanosheet for efficient bacterial infected wound healing

J Colloid Interface Sci. 2023 Aug:643:183-195. doi: 10.1016/j.jcis.2023.04.002. Epub 2023 Apr 7.

Authors

Hao Cheng¹, Niuniu Wang², Yongqiang Yang³, Xiong Jiao⁴, Peide Han⁵, Wangping Duan⁶, Di Huang⁷, Meiwen An⁴, Weiyi Chen⁴, Xiaohong Yao⁸, Xiangyu Zhang⁹

Affiliations

¹ Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
² Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
³ National Graphene Products Quality Inspection and Testing Center (Jiangsu), Special Equipment Safety Supervision Inspection Institute of Jiangsu Province, Wuxi 214174, China.
⁴ Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
⁵ College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
⁶ Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
⁷ Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan 030032, China.
⁸ Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China. Electronic address: xhyao@tyut.edu.cn.
⁹ Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan 030001, China. Electronic address: zhangxiangyu@tyut.edu.cn.

PMID: 37058893
DOI: 10.1016/j.jcis.2023.04.002

Abstract

Graphitic carbon nitride (g-C₃N₄) has received much attention as a metal-free polymeric two-dimensional photocatalyst for antibiotic-free antibacterial application. However, the weak photocatalytic antibacterial activity of pure g-C₃N₄ stimulated by visible light limits its applications. Herein, g-C₃N₄ is modified with Zinc (II) meso-tetrakis (4-carboxyphenyl) porphyrin (ZnTCPP) by amidation reaction to enhance the utilization of visible light and reduce the recombination of electron-hole pairs. The composite (ZP/CN) is used to treat bacterial infection under visible light irradiation with a high efficacy of 99.99% within 10 min due to the enhanced photocatalytic activity. Ultraviolet photoelectron spectroscopy and density flooding theory calculations indicate the excellent electrical conductivity between the interface of ZnTCPP and g-C₃N₄. The formed built-in electric field is responsible for the high visible photocatalytic performance of ZP/CN. In vitro and in vivo tests have demonstrated that ZP/CN not only possesses excellent antibacterial activity upon visible light irradiation, but also facilitates the angiogenesis. In addition, ZP/CN also suppresses the inflammatory response. Therefore, this inorganic-organic material can serve as a promising platform for effective healing of bacteria-infected wounds.

Keywords: Angiogenesis; Antibacterial; Photocatalytic; Visible light; Wound healing.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Bacteria
Light
Porphyrins* / pharmacology
Zinc* / pharmacology

Substances

zinc hematoporphyrin
zinc(II) tetrakis(4-carboxyphenyl)porphine
Zinc
Porphyrins
Anti-Bacterial Agents