miRNAs as potential game-changers in head and neck cancer: Future clinical and medicinal uses

Hesham A El-Mahdy; Ahmed M Mohamadin; Ahmed I Abulsoud; Emad Gamil Khidr; Ahmed A El-Husseiny; Ahmed Ismail; Elsayed G E Elsakka; Hamada Ahmed Mokhlis; Hussein M El-Husseiny; Ahmed S Doghish

doi:10.1016/j.prp.2023.154457

miRNAs as potential game-changers in head and neck cancer: Future clinical and medicinal uses

Pathol Res Pract. 2023 May:245:154457. doi: 10.1016/j.prp.2023.154457. Epub 2023 Apr 10.

Affiliations

¹ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt. Electronic address: heshamabbas@azhar.edu.eg.
² Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt.
³ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt; Department of Biochemistry and Biotechnology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
⁴ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt; Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr, Cairo 11829, Egypt.
⁵ Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Nasr, Cairo 11231, Egypt.
⁶ Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai Cho, Fuchu-shi, Tokyo 183-8509, Japan; Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Al Qalyubia 13736, Egypt.
⁷ Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr, Cairo 11829, Egypt; Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt. Electronic address: ahmed_doghish@azhar.edu.eg.

PMID: 37058745
DOI: 10.1016/j.prp.2023.154457

Abstract

Head and neck cancers (HNCs) are a group of heterogeneous tumors formed most frequently from epithelial cells of the larynx, lips, oropharynx, nasopharynx, and mouth. Numerous epigenetic components, including miRNAs, have been demonstrated to have an impact on HNCs characteristics like progression, angiogenesis, initiation, and resistance to therapeutic interventions. The miRNAs may control the production of numerous genes linked to HNCs pathogenesis. The roles that miRNAs play in angiogenesis, invasion, metastasis, cell cycle, proliferation, and apoptosis are responsible for this impact. The miRNAs also have an impact on crucial HNCs-related mechanistic networks like the WNT/β-catenin signaling, PTEN/Akt/mTOR pathway, TGFβ, and KRAS mutations. miRNAs may affect how the HNCs respond to treatments like radiation and chemotherapy in addition to pathophysiology. This review aims to demonstrate the relationship between miRNAs and HNCs with a particular emphasis on how miRNAs impact HNCs signaling networks.

Keywords: Drug resistance; HNCs; Oncogenic miR; Pathogenesis; Tumor suppressor miR.

Publication types

Review

MeSH terms

Cell Proliferation / genetics
Gene Expression Regulation, Neoplastic
Head and Neck Neoplasms* / genetics
Head and Neck Neoplasms* / therapy
Humans
MicroRNAs* / genetics
MicroRNAs* / metabolism
Wnt Signaling Pathway

Substances

MicroRNAs