Cryopreventive temperatures prior to chemotherapy

A Ibrahim; E Camci; L Khairallah; M Jontell; J Walladbegi

doi:10.1007/s12032-023-01989-9

Cryopreventive temperatures prior to chemotherapy

Med Oncol. 2023 Apr 14;40(5):148. doi: 10.1007/s12032-023-01989-9.

Authors

A Ibrahim¹, E Camci², L Khairallah², M Jontell³, J Walladbegi²

Affiliations

¹ Department of Oral and Maxillofacial Surgery, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, PO Box 450, 405 30, Gothenburg, Sweden. aram.ibrahim@gu.se.
² Department of Oral and Maxillofacial Surgery, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, PO Box 450, 405 30, Gothenburg, Sweden.
³ Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Abstract

The superiority of oral cryotherapy (OC) for prevention of chemotherapy-induced oral mucositis (OM) has been demonstrated in several trials. In clinical settings, cooling is usually initiated prior to the chemotherapy infusion. It then continues during the infusion, and for a period after the infusion has been completed. While the cooling period post-infusion depends on the half-life of the chemotherapeutic drug, there is no consensus on when cooling should be initiated prior to the infusion. The lowest achieved temperature in the oral mucosa is believed to provide the best condition for OM prevention. Given this, it was of interest to investigate when along the course of intraoral cooling this temperature is achieved. In total, 20 healthy volunteers participated in this randomized crossover trial. Each subject attended three separate cooling sessions of 30 min each, with ice chips (IC) and the intraoral cooling device (ICD) set to 8 and 15 °C, respectively. At baseline and following 5, 10, 15, 20 and 30 min of cooling, intraoral temperatures were registered using a thermographic camera. The greatest drop in intraoral temperature was seen after 5 min of cooling with IC, ICD^8°C and ICD^15°C, respectively. A statistically significant difference, corresponding to 1.4 °C, was seen between IC and the ICD^15°C (p < 0.05). The intraoral temperature further declined throughout the 30 min of cooling, showing an additional temperature reduction of 3.1, 2.2, and 1.7 °C for IC, ICD^8°C and ICD^15°C, respectively.

Keywords: Cryotherapy; Intraoral cooling device; Oral mucositis; Tolerability.

Publication types

Randomized Controlled Trial

MeSH terms

Cryotherapy*
Humans
Mouth Mucosa
Stomatitis* / chemically induced
Stomatitis* / prevention & control
Temperature