A systematic review and meta-analysis of the seroconversion rates and adverse effects of COVID-19 mRNA vaccine and COVID-19 viral vector vaccine in kidney transplant recipient patients

Hum Vaccin Immunother. 2023 Dec 31;19(1):2196893. doi: 10.1080/21645515.2023.2196893. Epub 2023 Apr 14.

Abstract

Patients received kidney transplantation (KTR) have a low seroconversion rate after vaccination. Our objective was to compare the seroconversion rates and adverse effects of additional different vaccinations in KTR patients in existing studies. Databases such as PubMed, Cochrane Library, Web of Science, Embase, ClinicalTrials.gov and others. Three high-quality RCT were included and showed no statistical difference in seroconversion rates between the two vaccines (RR = 0.93[0.76,1.13]). There was no statistical difference in seroconversion rates between the sexes, for men (RR = 0.93[0.69,1.25]) and women (RR = 0.91[0.62,1.33]). Among the adverse effects there was no statistically significant difference in fever (RR = 1.06[0.44,2.57]), while for injection site pain there was a statistically significant difference (RR = 1.14[1.18,1.84]). There was no significant difference in seroconversion rates in patients with KTR who received the two additional vaccines. Patients injected with the viral vector vaccine were less painful than those injected with the mRNA vaccine.

Keywords: COVID-19; adverse effects; kidney transplant recipient; mRNA vaccine; seroconversion rate; viral vector vaccine.

Publication types

  • Meta-Analysis
  • Systematic Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral
  • COVID-19 Vaccines* / adverse effects
  • COVID-19* / prevention & control
  • Female
  • Humans
  • Kidney Transplantation*
  • Male
  • Seroconversion
  • Vaccination / adverse effects

Substances

  • Antibodies, Viral
  • COVID-19 Vaccines

Grants and funding

This work was supported by Shaanxi Provincial Administration of Chinese Medicine “Double Chain Integration” Middle-aged and Young Research Innovation Team Project#1 under Grant [2022-SLRH-YQ-008]; Shaanxi University of Chinese Medicine Discipline Innovation Team Program under Grant [2019-QN02]; Shaanxi University of Chinese Medicine Innovative Team Project for Research on the Theory of Medicinal Properties of Chinese Medicine under Grant [2020XKTD-A04]; Shaanxi Province Special Support Program Talent Project.