Synthesis and crystal structure of N-(5-acetyl-4-methyl-pyrimidin-2-yl)benzene-sulfonamide

Reham A Mohamed-Ezzat; Benson M Kariuki; Rasha A Azzam

doi:10.1107/S2056989023001871

Synthesis and crystal structure of N-(5-acetyl-4-methyl-pyrimidin-2-yl)benzene-sulfonamide

Acta Crystallogr E Crystallogr Commun. 2023 Mar 15;79(Pt 4):331-334. doi: 10.1107/S2056989023001871. eCollection 2023 Mar 1.

Authors

Reham A Mohamed-Ezzat¹, Benson M Kariuki², Rasha A Azzam³

Affiliations

¹ Chemistry of Natural & Microbial Products Department, National Research Center, Cairo, Egypt.
² School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10, 3AT, United Kingdom.
³ Department of Chemistry, Helwan University, Cairo, Egypt.

Abstract

N-(5-Acetyl-4-methyl-pyrimidin-2-yl)benzene-sulfonamide, C₁₃H₁₃N₃O₃S, was sythesized and characterized by single-crystal X-ray diffraction. In the crystal, π-π inter-actions between the phenyl and pyrimidine groups of neighbouring mol-ecules form mol-ecular chains parallel to [010]. Adjacent mol-ecular chains are linked by N-H⋯N hydrogen-bonding inter-actions between the pyrimidine and amine groups of neighbouring mol-ecules, resulting in a three-dimensional network.

Keywords: X-ray diffraction; crystal structure; pyrimidine sulfonamide; synthesis.

Grants and funding

We thank Helwan University for funding this research.