Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention

Xiaoying Yin; Xinxin Yin; Xin Pan; Jingyu Zhang; Xinhui Fan; Jiaxin Li; Xiaoxuan Zhai; Lijun Jiang; Panpan Hao; Jiali Wang; Yuguo Chen

doi:10.3389/fphar.2023.1070973

Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention

Front Pharmacol. 2023 Mar 28:14:1070973. doi: 10.3389/fphar.2023.1070973. eCollection 2023.

Authors

Xiaoying Yin^{1

2

3

4}, Xinxin Yin^{1

2

3

4}, Xin Pan^{1

2

3

4}, Jingyu Zhang^{1

2

3

4}, Xinhui Fan^{1

2

3

4}, Jiaxin Li^{1

2

3

4}, Xiaoxuan Zhai^{1

2

3

4}, Lijun Jiang^{1

2

3

4}, Panpan Hao⁴, Jiali Wang^{1

2

3

4}, Yuguo Chen^{1

2

3

4}

Affiliations

¹ Department of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.
² Clinical Research Center for Emergency and Critical Care Medicine of Shandong Province, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan, China.
³ Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, China.
⁴ Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China.

Abstract

Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix collagen deposition are the hallmarks of cardiac fibrosis, which are modulated by multiple signaling pathways and various types of cells in time-dependent manners. Our understanding of the development of cardiac fibrosis after MI has evolved in basic and clinical researches, and the regulation of fibrotic remodeling may facilitate novel diagnostic and therapeutic strategies, and finally improve outcomes. Here, we aim to elaborate pathophysiology, examination and intervention of cardiac fibrosis after MI.

Keywords: antifibrotic therapy; cardiac remodeling; extracellular matrix; fibroblast; fibrosis; myocardial infarction; myofibroblast.

Publication types

Review

Grants and funding

This study was supported by the State Key Program of the National Natural Science Foundation of China (82030059), National Natural Science Foundation of China (81772036, 82072144,81873950, 82172178, 81873953), National Key R&D Program of China (2020YFC1512700, 2020YFC1512705, 2020YFC1512703), National S&T Fundamental Resources Investigation Project (2018FY100600, 2018FY100602), Key R&D Program of Shandong Province (2021ZLGX02, 2021SFGC0503), Taishan Pandeng Scholar Program of Shandong Province (tspd20181220), Taishan Young Scholar Program of Shandong Province (tsqn20161065, tsqn201812129), Youth Top-Talent Project of National Ten Thousand Talents Plan, Qilu Young Scholar Program and the Fundamental Research Funds of Shandong University (2018JC011).