Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases

Cheng-Mei Tian; Mei-Feng Yang; Hao-Ming Xu; Min-Zheng Zhu; Yuan Zhang; Jun Yao; Li-Sheng Wang; Yu-Jie Liang; De-Feng Li

doi:10.1155/2023/4245704

Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases

Stem Cells Int. 2023 Apr 4:2023:4245704. doi: 10.1155/2023/4245704. eCollection 2023.

Authors

Cheng-Mei Tian^{1

2}, Mei-Feng Yang³, Hao-Ming Xu⁴, Min-Zheng Zhu⁴, Yuan Zhang⁵, Jun Yao¹, Li-Sheng Wang¹, Yu-Jie Liang⁶, De-Feng Li¹

Affiliations

¹ Department of Gastroenterology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
² Department of Emergency, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020 Guangdong, China.
³ Department of Hematology, Yantian District People's Hospital, Shenzhen, Guangdong, China.
⁴ Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
⁵ Department of Medical Administration, Huizhou Institute of Occupational Diseases Control and Prevention, Huizhou, Guangdong, China.
⁶ Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen, Guangdong, China.

Abstract

As double membrane-encapsulated nanovesicles (30-150 nm), exosomes (Exos) shuttle between different cells to mediate intercellular communication and transport active cargoes of paracrine factors. The anti-inflammatory and immunomodulatory activities of mesenchymal stem cell (MSC)-derived Exos (MSC-Exos) provide a rationale for novel cell-free therapies for inflammatory bowel disease (IBD). Growing evidence has shown that MSC-Exos can be a potential candidate for treating IBD. In the present review, we summarized the most critical advances in the properties of MSC-Exos, provided the research progress of MSC-Exos in treating IBD, and discussed the molecular mechanisms underlying these effects. Collectively, MSC-Exos had great potential for cell-free therapy in IBD. However, further studies are required to understand the full dimensions of the complex Exo system and how to optimize its effects.

Publication types

Review