Influence of topical capsaicin cream on thermoregulation and perception during acute exercise in the heat

Alejandro M Rosales; Marie Powers; Matthias J Walters; Mark L McGlynn; Christopher W Collins; Dustin R Slivka

doi:10.1016/j.jtherbio.2023.103535

Influence of topical capsaicin cream on thermoregulation and perception during acute exercise in the heat

J Therm Biol. 2023 Apr:113:103535. doi: 10.1016/j.jtherbio.2023.103535. Epub 2023 Mar 2.

Authors

Alejandro M Rosales¹, Marie Powers², Matthias J Walters², Mark L McGlynn², Christopher W Collins², Dustin R Slivka³

Affiliations

¹ School of Health and Kinesiology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA; School of Integrative Physiology and Athletic Training, Montana Center for Work Physiology and Exercise Metabolism, University of Montana, 32 Campus Drive, Missoula, MT, 59812, USA.
² School of Health and Kinesiology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA.
³ School of Health and Kinesiology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, NE, 68182, USA; School of Integrative Physiology and Athletic Training, Montana Center for Work Physiology and Exercise Metabolism, University of Montana, 32 Campus Drive, Missoula, MT, 59812, USA. Electronic address: dustin.slivka@mso.umt.edu.

PMID: 37055138
DOI: 10.1016/j.jtherbio.2023.103535

Abstract

Purpose: Determine if topical capsaicin, a transient receptor potential vanilloid heat thermoreceptor activator, alters thermoregulation and perception when applied topically prior to thermal exercise.

Methods: Twelve subjects completed 2 treatments. Subjects walked (1.6 m s^-1, 5% grade) for 30 min in the heat (38 °C, 60% relative humidity) with either a capsaicin (0.025% capsaicin) or control cream applied to the upper (shoulder to wrist) and lower (mid-thigh to ankle) limbs covering ∼50% body surface area. Skin blood flow (SkBF), sweat (rate, composition), heart rate, temperature (skin, core), and perceived thermal sensation were measured prior to and during exercise.

Results: The relative change in SkBF was not different between treatments at any time point (p = 0.284). There were no differences in sweat rate between the capsaicin (1.23 ± 0.37 L h^-1) and control (1.43 ± 0.43 L h^-1, p = 0.122). There were no differences in heart rate between the capsaicin (122 ± 38 beats·min^-1) and control (125 ± 39 beats·min^-1, p = 0.431). There were also no differences in weighted surface (p = 0.976) or body temperatures (p = 0.855) between the capsaicin (36.0 ± 1.7 °C, 37.0 ± 0.8 °C, respectively) and control (36.0 ± 1.6 °C, 36.9 ± 0.8 °C, respectively). The capsaicin treatment was not perceived as hotter than the control treatment until minute 30 of exercise (2.8 ± 0.4, 2.5 ± 0.5, respectively, p = 0.038) CONCLUSIONS: Topical capsaicin application does not alter whole-body thermoregulation during acute exercise in the heat despite perceiving the treatment as hotter late in exercise.

Keywords: Core temperature; Skin blood flow; Skin temperature; Sweat rate; Thermoreception; Transient receptor potential vanilloid.

MeSH terms

Body Temperature / physiology
Body Temperature Regulation / physiology
Capsaicin* / pharmacology
Exercise / physiology
Hot Temperature*
Humans
Perception
Skin Temperature
Sweating

Substances

Capsaicin