HIV establishes an early foothold

Jose A Moran; Matthew D Marsden

doi:10.1016/j.chom.2023.03.012

HIV establishes an early foothold

Cell Host Microbe. 2023 Apr 12;31(4):571-573. doi: 10.1016/j.chom.2023.03.012.

Authors

Jose A Moran¹, Matthew D Marsden²

Affiliations

¹ Department of Microbiology & Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA, USA.
² Department of Microbiology & Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Medicine (Division of Infectious Diseases), School of Medicine, University of California Irvine, Irvine, CA, USA. Electronic address: mdmarsde@hs.uci.edu.

PMID: 37054675
DOI: 10.1016/j.chom.2023.03.012

Abstract

The weeks following HIV acquisition are a critical time when the virus causes significant immunological damage and establishes long-term latent reservoirs. A recent study in Immunity by Gantner et al. uses single-cell analysis to explore these key early infection events, providing insights into early HIV pathogenesis and reservoir formation.

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MeSH terms

CD4-Positive T-Lymphocytes
HIV Infections*
Humans
Virus Latency