GPI anchors: Regulated as needed

Auxiliadora Aguilera-Romero; Manuel Muñiz

doi:10.1083/jcb.202303097

GPI anchors: Regulated as needed

J Cell Biol. 2023 May 1;222(5):e202303097. doi: 10.1083/jcb.202303097. Epub 2023 Apr 13.

Authors

Auxiliadora Aguilera-Romero^{1

2}, Manuel Muñiz^{1

2}

Affiliations

¹ Department of Cell Biology, Faculty of Biology, University of Seville, Seville, Spain.
² Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla , Seville, Spain.

Abstract

GPI anchoring is an essential post-translational modification in eukaryotes that links proteins to the plasma membrane. In this issue, Liu et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202208159) suggest, for the first time, a regulation on demand of the GPI glycolipid precursor biosynthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Membrane
Glycolipids / biosynthesis
Glycolipids / chemistry
Glycosylphosphatidylinositols* / biosynthesis
Glycosylphosphatidylinositols* / chemistry
Protein Processing, Post-Translational*

Substances

Glycolipids
Glycosylphosphatidylinositols