The aim of this study was to study the effect of zinc oxide-chitosan nanoparticles (Zn-CNPs) on growth performance, plasma constituents, carcass indices, and immune function in rabbit diets. Eighty weaned V-line males rabbits at 5 weeks of age were divided into four dietary groups of control diet; 50 Zn-CNPs; 75 Zn-CNPs;100 Zn-CNPs. Supplementation of Zn-CNPs did not affect final live body weight and average daily weight gain. 100 ppm Zn-CNPs recorded (p < 0.05) higher digestibility of DM, OM, CP, EE, and NFE. Dietary groups of 75 and 100 ppm were higher (p < 0.05) in DCP, TDN (%), and DE (kcal/kg). Zn-CNPs supplementation was higher (p < 0.05) in hot carcass and spleen weights %. The addition of Zn-CNPs in diets promoted dressing%. Significant increases (p < 0.05) in plasma total protein and albumin levels for 75 and 100 Zn-CNPs. Zn-CNPs decreased (p < 0.05) glucose, total cholesterol, LDL concentrations and increased (p < 0.05) plasma zinc levels, IgG, IgM. Plasma HDL level increased (p < 0.05) with 75 and 100 ppm Zn-CNPs. In conclusion, Zn-CNPs supplementations can use safely as a zinc source in rabbits diets without any detrimental effects on growth performance, plasma constituents, and carcass indices. Moreover, 50, 75, and 100 ppm Zn-CNPs enhanced the immune functions.
Keywords: Growth performance; immune function; nanoparticles; zinc.