One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel-Crafts Alkylation of γ-Hydroxybutyrolactams

Vladimir T Abaev; Nicolai A Aksenov; Dmitrii A Aksenov; Elena V Aleksandrova; Alesia S Akulova; Igor A Kurenkov; Alexander V Leontiev; Alexander V Aksenov

doi:10.3390/molecules28073162

One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel-Crafts Alkylation of γ-Hydroxybutyrolactams

Molecules. 2023 Apr 2;28(7):3162. doi: 10.3390/molecules28073162.

Authors

Vladimir T Abaev^{1

2}, Nicolai A Aksenov², Dmitrii A Aksenov², Elena V Aleksandrova², Alesia S Akulova², Igor A Kurenkov², Alexander V Leontiev², Alexander V Aksenov²

Affiliations

¹ Department of Chemistry, Biology and Biotechnology, North-Ossetian State University Named after K. L. Khetagurov, 46 Vatutin St., Vladikavkaz 362025, Russia.
² Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355009, Russia.

Abstract

The Friedel-Crafts reaction of novel 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones was used for low cost, one-pot preparation of polycyclic indole derivatives structurally similar to Ergot alkaloids.

Keywords: cascade transformations; intramolecular Friedel–Crafts reaction; polycyclic indoles.

Grants and funding

21-73-00044/Russian Science Foundation