New Triterpenoids and Anti-Inflammatory Constituents from Glinus oppositifolius

Jih-Jung Chen; Chang-Syun Yang; Yu-Hui Chen; Che-Yi Chao; Yu-Chang Chen; Yeuh-Hsiung Kuo

doi:10.3390/molecules28072903

New Triterpenoids and Anti-Inflammatory Constituents from Glinus oppositifolius

Molecules. 2023 Mar 23;28(7):2903. doi: 10.3390/molecules28072903.

Authors

Jih-Jung Chen^{1

2}, Chang-Syun Yang¹, Yu-Hui Chen³, Che-Yi Chao⁴, Yu-Chang Chen⁵, Yeuh-Hsiung Kuo^{3

6

7}

Affiliations

¹ Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
² Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.
³ Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404327, Taiwan.
⁴ Department of Food Nutrition and Health Biotechnology, Asia University, Taichung 41354, Taiwan.
⁵ School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807377, Taiwan.
⁶ Chinese Medicine Research Center, China Medical University, Taichung 404327, Taiwan.
⁷ Department of Biotechnology, Asia University, Taichung 413305, Taiwan.

Abstract

Three new triterpenoids-spergulagenin B (1), spergulagenin C (2), and spergulagenin D (3)-were isolated from the aerial part of Glinus oppositifolius, along with 17 known compounds (4-20). The structures of these new compounds were identified by spectroscopic and MS analyses. Compounds 3, 5, 19, and 20 were evaluated for inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells with IC₅₀ values of 17.03, 18.21, 16.30, and 12.64 μM, respectively. Compounds 3, 5, and 20 exhibited inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 cells with IC₅₀ values of 18.35 ± 1.34, 17.56 ± 1.41, and 14.27 ± 1.29 μM, respectively.

Keywords: Glinus oppositifolius; Molluginaceae; anti-inflammatory activity; spergulagenin A; spergulagenin B; spergulagenin C; triterpenoids.

MeSH terms

Animals
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / pharmacology
Lipopolysaccharides / pharmacology
Mice
Molecular Structure
Molluginaceae* / chemistry
Nitric Oxide
RAW 264.7 Cells
Triterpenes* / chemistry
Triterpenes* / pharmacology

Substances

Triterpenes
Nitric Oxide
Lipopolysaccharides
Anti-Inflammatory Agents

Grants and funding

This study was supported by a grant from the Ministry of Science and Technology (MOST), Taiwan (No. MOST 109-2320-B-010-029-MY3), awarded to J.-J. Chen.