Hydrogel-Inducing Graphene-Oxide-Derived Core-Shell Fiber Composite for Antibacterial Wound Dressing

Yuliya Kan; Julia V Bondareva; Eugene S Statnik; Elizaveta V Koudan; Evgeniy V Ippolitov; Mikhail S Podporin; Polina A Kovaleva; Roman R Kapaev; Alexandra M Gordeeva; Julijana Cvjetinovic; Dmitry A Gorin; Stanislav A Evlashin; Alexey I Salimon; Fedor S Senatov; Alexander M Korsunsky

doi:10.3390/ijms24076255

Hydrogel-Inducing Graphene-Oxide-Derived Core-Shell Fiber Composite for Antibacterial Wound Dressing

Int J Mol Sci. 2023 Mar 26;24(7):6255. doi: 10.3390/ijms24076255.

Authors

Yuliya Kan¹, Julia V Bondareva¹, Eugene S Statnik¹, Elizaveta V Koudan², Evgeniy V Ippolitov³, Mikhail S Podporin³, Polina A Kovaleva², Roman R Kapaev^{1

4}, Alexandra M Gordeeva¹, Julijana Cvjetinovic¹, Dmitry A Gorin¹, Stanislav A Evlashin¹, Alexey I Salimon^{1

2}, Fedor S Senatov², Alexander M Korsunsky^{1

5}

Affiliations

¹ Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia.
² Center for Biomedical Engineering, National University of Science and Technology 'MISIS', Leninskiy pr. 4, 119049 Moscow, Russia.
³ Department of Microbiology, Virology, Immunology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Delegatskaya St. 20, 127473 Moscow, Russia.
⁴ Department of Chemistry and BINA-BIU Center for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel.
⁵ Multi-Beam Laboratory for Engineering Microscopy, Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK.

Abstract

The study reveals the polymer-crosslinker interactions and functionality of hydrophilic nanofibers for antibacterial wound coatings. Coaxial electrospinning leverages a drug encapsulation protocol for a core-shell fiber composite with a core derived from polyvinyl alcohol and polyethylene glycol with amorphous silica (PVA-PEG-SiO₂), and a shell originating from polyvinyl alcohol and graphene oxide (PVA-GO). Crosslinking with GO and SiO₂ initiates the hydrogel transition for the fiber composite upon contact with moisture, which aims to optimize the drug release. The effect of hydrogel-inducing additives on the drug kinetics is evaluated in the case of chlorhexidine digluconate (CHX) encapsulation in the core of core-shell fiber composite PVA-PEG-SiO₂-1x-CHX@PVA-GO. The release rate is assessed with the zero, first-order, Higuchi, and Korsmeyer-Peppas kinetic models, where the inclusion of crosslinking silica provides a longer degradation and release rate. CHX medicated core-shell composite provides sustainable antibacterial activity against Staphylococcus aureus.

Keywords: crosslinking; graphene oxide; nanofiber; silica; wound dressing.

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Bandages
Graphite* / pharmacology
Hydrogels / pharmacology
Nanofibers* / therapeutic use
Polyvinyl Alcohol
Silicon Dioxide

Substances

graphene oxide
Graphite
Polyvinyl Alcohol
Silicon Dioxide
Hydrogels
Anti-Bacterial Agents

Grants and funding

This work was supported by the Federal Academic Leadership program ’Priority 2030’ under the ‘Increase Competitiveness’ program of the National University of Science and Technology ‘MISIS’ (grant number K1-2022-032).