Sleep sharp wave ripple and its functions in memory and synaptic plasticity

Zhiwen Zhou; Hiroaki Norimoto

doi:10.1016/j.neures.2023.01.011

Sleep sharp wave ripple and its functions in memory and synaptic plasticity

Neurosci Res. 2023 Apr:189:20-28. doi: 10.1016/j.neures.2023.01.011. Epub 2023 Apr 10.

Authors

Zhiwen Zhou¹, Hiroaki Norimoto²

Affiliations

¹ Graduate School of Medicine, Hokkaido University, West 7 North 15 Kita-ku, Sapporo, Hokkaido 060-8638, Japan. Electronic address: zzhou@pop.med.hokudai.ac.jp.
² Graduate School of Medicine, Hokkaido University, West 7 North 15 Kita-ku, Sapporo, Hokkaido 060-8638, Japan. Electronic address: norimoto@pop.med.hokudai.ac.jp.

PMID: 37045494
DOI: 10.1016/j.neures.2023.01.011

Abstract

Memory is one of the fundamental cognitive functions of brain. The formation and consolidation of memory depend on the hippocampus and sleep. Sharp wave ripple (SWR) is an electrophysiological event which is most frequently observed in the hippocampus during sleep. It represents a highly synchronized neuronal activity pattern which modulates numerous brain regions including the neocortex, subcortical areas, and the hippocampus itself. In this review, we discuss how SWRs link experiences to memories and what happens in the hippocampus and other brain regions during sleep by focusing on synaptic plasticity.

Publication types

Review

MeSH terms

Hippocampus* / physiology
Neocortex*
Neuronal Plasticity
Neurons / physiology
Sleep / physiology