Objectives: To validate the peak enhancement timing of a patient-specific post-trigger delay (PTD) in Coronary CT angiography (CCTA) and compare its image quality against a fixed PTD.
Methods: In this prospective study, 204 consecutive participants were randomly divided into two groups to perform CCTA in bolus tracking with either a fixed 5-second PTD (Group A) or a patient-specific PTD (Group B). Test bolus was also performed in Group B to determine the reference peak enhancement timing. One reader evaluated objective image quality, while two readers rated subjective image quality. The predicted PTD was validated through correlation and agreement analysis with the reference measurement. Objective image quality was compared between groups via two-sample t-test and linear regression, while the subjective ratings were compared with chi-square analysis.
Results: The two groups each had 102 participants with comparable characteristics (52.9 ± 11.3 versus 52.1 ± 11.3 years of age, and 53 versus 52 males). The scan timing from patient-specific PTD demonstrated strong correlation (R = 0.77) and consistency (ICC = 0.618) with the reference peak timing. Both readers rated better subjective image quality for the Group B (p < 0.001). The mean vessel enhancement was significantly higher in Group B in all coronary vessels (all p < 0.05). After adjusting for the participant variation, the patient-specific PTD strategy was associated with an average of 33.5 HU higher enhancement compared to the fixed PTD.
Conclusions: Patient-specific delay could achieve reliable scan timing, optimize vessel opacification and obtain better image quality in CCTA.
Keywords: Computed tomography angiography; Contrast media; Coronary vessels.
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