With the improvement of DNA methylation detection techniques, studies on age-related methylation sites have found more age-specific ones across tissues, which improves the sensitivity and accuracy of age estimation. In addition, the establishment of various statistical models also provides a new direction for the age estimation of tissues from different sources. This review summarizes the related studies of age estimation based on DNA methylation from the aspects of detection technology, age-related cytosine phosphate guanine site and model selection in recent years.
随着DNA甲基化检测技术的发展，年龄相关甲基化修饰位点的研究发现了更多跨组织的年龄特异性位点，这使得个体年龄推断的灵敏度和准确性都有了提高。此外，各种统计模型的建立，也为不同来源组织的年龄推断提供了新的方向。本文从检测技术、年龄相关胞嘧啶鸟嘌呤二核苷酸位点和模型的选择等方面，对近年来DNA甲基化位点年龄推断的相关研究进行综述。.
Keywords: DNA methylation; age estimation; epigenetics; forensic genetics; review.