Rubochingosides A - J, labdane-type diterpene glycosides from leaves of Rubus chingii

Jianxiong Wang; Xiaowu Xiao; Nian Zhou; Minmin Zhao; Shuqin Lang; Qi Ren; Dong Wang; Huizheng Fu

doi:10.1016/j.phytochem.2023.113670

Rubochingosides A - J, labdane-type diterpene glycosides from leaves of Rubus chingii

Phytochemistry. 2023 Jun:210:113670. doi: 10.1016/j.phytochem.2023.113670. Epub 2023 Apr 8.

Authors

Jianxiong Wang¹, Xiaowu Xiao², Nian Zhou², Minmin Zhao¹, Shuqin Lang¹, Qi Ren², Dong Wang³, Huizheng Fu⁴

Affiliations

¹ Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality, Nanchang, Jiangxi, 330029, China; Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, China.
² Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality, Nanchang, Jiangxi, 330029, China.
³ Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, China; Jiangxi General Institute of Inspection, Testing and Certification, Nanchang, Jiangxi, 330052, China. Electronic address: jxdcwd@126.com.
⁴ Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality, Nanchang, Jiangxi, 330029, China; Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, China. Electronic address: fhzfhz620@sohu.com.

PMID: 37037403
DOI: 10.1016/j.phytochem.2023.113670

Abstract

Ten previously undescribed labdane-type triterpenoids, rubochingosides A - J (1-10), were isolated from the leaves of Rubus chingii Hu. Their structures were elucidated by spectroscopic and chemical methods. The cytotoxicity of all isolated compounds was tested against five human tumor cell lines (Bel-7402, Caski, BGC-823, A2780, and HCT-116). Among them, compounds 4 and 8 showed cytotoxic activities against Bel-7402 and A2780 cells with IC₅₀ values of 10.43 ± 0.51 and 29.03 ± 2.94 μM, respectively; Compound 8 exhibited cytotoxic activities against Bel-7402 and HCT-116 cells with IC₅₀ values of 17.78 ± 1.54 and 26.23 ± 6.14 μM, respectively.

Keywords: Cytotoxic activities; Diterpene glycosides; Rosaceae; Rubochingosides A - J; Rubus chingii; Structure elucidation.

MeSH terms

Cell Line, Tumor
Diterpenes* / analysis
Diterpenes* / pharmacology
Female
Glycosides / chemistry
Humans
Molecular Structure
Ovarian Neoplasms*
Plant Leaves / chemistry
Rubus* / chemistry

Substances

Glycosides
Diterpenes