Interactions between gut microbes and NLRP3 inflammasome in the gut-brain axis

Ding Yang; Zixu Wang; Yaoxing Chen; Qingyun Guo; Yulan Dong

doi:10.1016/j.csbj.2023.03.017

Interactions between gut microbes and NLRP3 inflammasome in the gut-brain axis

Comput Struct Biotechnol J. 2023 Mar 25:21:2215-2227. doi: 10.1016/j.csbj.2023.03.017. eCollection 2023.

Authors

Ding Yang¹, Zixu Wang¹, Yaoxing Chen¹, Qingyun Guo², Yulan Dong¹

Affiliations

¹ College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
² Milu conservation research unit, Beijing Milu Ecological Research Center, Beijing 100163, China.

Abstract

The role of the gut-brain axis in maintaining the brain's and gut's homeostasis has been gradually recognized in recent years. The connection between the gut and the brain takes center stage. In this scenario, the nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome promotes inflammatory cell recruitment. It plays a crucial role in coordinating host physiology and immunity. Recent evidence shows how vital the gut-brain axis is for maintaining brain and gut homeostasis. However, more research is needed to determine the precise causal link between changed gut microbiota structure and NLRP3 activation in pathogenic circumstances. This review examines the connection between gut microbiota and the NLRP3 inflammasome. We describe how both dynamically vary in clinical cases and the external factors affecting both. Finally, we suggest that the crosstalk between the gut microbiota and NLRP3 is involved in signaling in the gut-brain axis, which may be a potential pathological mechanism for CNS diseases and intestinal disorders.

Keywords: Gut microbiota; Gut-brain axis; Inflammation; LPS; NLRP3 inflammasome; Neurological disorders.

Publication types

Review