The effect of shoulder muscle succinylcholine injection on the foreleg raising power: Sion's local paralysis

Sion Jo; Yu Chan Kye; Jungyoup Lee; Euigi Jung; Minwoo Kang; Byunghyun Kim; Dongsung Kim; Boyoung Park

doi:10.1016/j.heliyon.2023.e14468

The effect of shoulder muscle succinylcholine injection on the foreleg raising power: Sion's local paralysis

Heliyon. 2023 Mar 13;9(4):e14468. doi: 10.1016/j.heliyon.2023.e14468. eCollection 2023 Apr.

Authors

Sion Jo¹, Yu Chan Kye¹, Jungyoup Lee¹, Euigi Jung¹, Minwoo Kang¹, Byunghyun Kim¹, Dongsung Kim¹, Boyoung Park²

Affiliations

¹ Department of Emergency Medicine, Veterans Health Service Medical Center, Seoul, Republic of Korea.
² Department of Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea.

Abstract

Objective: We examined the change in foreleg raising power after Sion's local paralysis (SLP) with succinylcholine in the shoulder muscle.

Methods: A randomized, double blind, placebo-controlled, porcine study was designed and performed at a research institution. Ten male Korean native pigs were randomized into an intervention group (n = 5) and a control group (n = 5). The injection points were in the middle of the left trapezius muscle and the middle of the left deltoid muscle. The control group received 2 ml normal saline (NS), 1 ml injected in each point. The intervention group received 0.4 mg/kg succinylcholine diluted to 2 ml in NS, and 1 ml was injected in each point. To represent the foreleg raising power, the height of the left forelegs from baseline (experiment table) was measured. We measured the foreleg height and oxygen saturation at -4, -2, 0, +2, +4, +6, +8, +10, +20, +30, and +60 min.

Results: After SLP, foreleg height immediately declined in the intervention group. It recovered slightly for a few minutes and declined from 4 to 8 min. In the control group, foreleg height was relatively similar throughout the study period. A repeated-measure analysis of variance revealed a significant group × time interaction (F_10,80 = 2.37, P = 0.017), a significant main effect for group (F_1,8 = 6.25, P = 0.037), and a significant main effect for time (F_10,80 = 4.41, P < 0.001). Post hoc analysis demonstrated that the intervention group showed significantly less foreleg raising power than the control group at 0, 4, 6, 8, 20, and 30 min (P < 0.05).

Conclusions: Compared with the control group, the foreleg raising power in the intervention group immediately decreased significantly and persisted for a period after SLP, without hypoxia, in a pig model.

Keywords: Foreleg raising power; Neuromuscular blocking agent; Paralysis; Pig; Sion's local paralysis; Succinylcholine.