Temporal Trends in the Incidence and Mortality of Major Reproductive-Related Cancers in Women in Guangzhou From 2010 to 2020: A Joinpoint and Age-Period-Cohort Study

Suixiang Wang; Shan Liu; Zhiqiang Nie; Yexin Li; Ke Li; Huanzhu Liang; Qian Chen; Lin Wen; Huan Xu; Boheng Liang; Pengzhe Qin; Chunxia Jing

doi:10.3389/ijph.2023.1605300

Temporal Trends in the Incidence and Mortality of Major Reproductive-Related Cancers in Women in Guangzhou From 2010 to 2020: A Joinpoint and Age-Period-Cohort Study

Int J Public Health. 2023 Mar 23:68:1605300. doi: 10.3389/ijph.2023.1605300. eCollection 2023.

Authors

Suixiang Wang¹, Shan Liu², Zhiqiang Nie³, Yexin Li², Ke Li¹, Huanzhu Liang², Qian Chen², Lin Wen², Huan Xu¹, Boheng Liang¹, Pengzhe Qin¹, Chunxia Jing^{2

4}

Affiliations

¹ Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
² Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
³ Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
⁴ Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, China.

Abstract

Objective: To understand the temporal trends of cancer incidence and mortality in women in Guangzhou during the past 11 years and provide clues for future research. Methods: Data were obtained from the Guangzhou Cancer and Death Registry. Average annual percentage changes (AAPCs) in age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) were obtained by joinpoint regression. The age-period-cohort (APC) model was generated to quantify the effects of age, period, and cohort. Results: The ASIRs for cervical (AAPC = -4.3%) and ovarian (AAPC = -3.2%) cancers showed a downward trend during 2010-2020, and that for uterine cancer showed an upward trend. The ASMRs of breast (APC = 5.0%) and cervical (APC = 8.8%) cancers increased. The APC model highlights different age, period, and birth cohort effects depending on the cancer site. Conclusion: The ASIRs for cervical and ovarian cancers among women in Guangzhou showed a decreasing trend during the period. The APC model showed mortality for 4 cancers increased with age. Incidence and mortality decreased with increasing birth cohort. Annual reproductive cancer screening is recommended for women of appropriate age to reduce the disease burden.

Keywords: Guangzhou; age-period-cohort analysis; joinpoint regression; reproductive-related cancers; women.

MeSH terms

Cohort Effect
Cohort Studies
Female
Humans
Incidence
Neoplasms*
Registries

Grants and funding

This work was supported by the Guangzhou Western Medicine General Citation Project (20221A011069), Guangzhou Science and Technology Plan Project/Key Research Plan (202206080008) and the Natural Science Foundation of Guangdong Province (NO. 2022A1515011672).