Anatomic distribution of lower extremity deep venous thrombosis is associated with an increased risk of pulmonary embolism: A 10-year retrospective analysis

Jianjun Zhang; Yan Chen; Zhicong Wang; Xi Chen; Yuehong Liu; Mozhen Liu

doi:10.3389/fcvm.2023.1154875

Anatomic distribution of lower extremity deep venous thrombosis is associated with an increased risk of pulmonary embolism: A 10-year retrospective analysis

Front Cardiovasc Med. 2023 Mar 22:10:1154875. doi: 10.3389/fcvm.2023.1154875. eCollection 2023.

Authors

Jianjun Zhang¹, Yan Chen¹, Zhicong Wang^{1

2}, Xi Chen¹, Yuehong Liu¹, Mozhen Liu²

Affiliations

¹ Department of Orthopedics, People's Hospital of Deyang City, Deyang, China.
² Department of Orthopedics, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Abstract

Aims: To investigate the potential relationship between anatomic distribution of lower extremity deep venous thrombosis (LEDVT) and pulmonary embolism (PE).

Methods: A retrospective case-control study was performed in patients diagnosed with LEDVT, which were confirmed by bilateral lower extremity compression ultrasonography (CUS) examination. According to the ultrasound reports, thrombus sidedness was categorized as unilateral and bilateral lower extremity, thrombus location was classified into distal and proximal LEDVT. Anatomic distributions of LEDVT were further subdivided depending on the combination of thrombus sidedness and location. Patients with PE were identified using the International Classification of Diseases-10 (ICD-10) codes (I26.0 and I26.9), and divided into PE group and Non-PE group. Univariate and multivariate logistic regression analyses were used to assess the association between anatomic distribution of LEDVT and PE. Sensitivity analyses were also conducted.

Results: A total of 2,363 consecutive patients with LEDVT were included, of whom 66.10% and 33.90% were unilateral and bilateral LEDVT, as well as 71.39% and 28.61% were isolated distal and proximal LEDVT, respectively. After the diagnosis of LEDVT, 185 patients (7.83%) developed PE. The proportions of PE ranged between the lowest (4.07%) in unilateral-distal LEDVT and highest (14.55%) in bilateral-proximal LEDVT. Multivariate logistic regression analysis showed that bilateral LEDVT (odds ratios [OR] = 2.455, 95% confidence interval [CI]: 1.803-3.344, P < 0.001) and proximal LEDVT (OR = 1.530, 95% CI: 1.105-2.118, P = 0.010) were risk factors for developing PE. Moreover, unilateral-proximal (OR = 2.129, 95% CI: 1.365-3.320, P = 0.00), bilateral-distal (OR = 3.193, 95% CI: 2.146-4.752, P < 0.001) and bilateral-proximal LEDVT(OR = 3.425, 95% CI: 2.093-5.603, P < 0.001) were significantly associated with an increased risk of PE. Sensitivity analyses also confirmed the robustness of these associations.

Conclusion: Patients with unilateral-proximal, bilateral-distal or bilateral-proximal are more likely to suffer from PE than those with unilateral-distal LEDVT.

Keywords: anatomic distribution; compression ultrasonography; lower extremity deep venous thrombosis; pulmonary embolism; risk factor.

Grants and funding

This study was supported by Sichuan Science and Technology Program (2021JDR0337, 2020YFS0520), and Health and Family Planning Commission of Sichuan Province (20PJ249, 20PJ250).