Bone regeneration strategies based on organelle homeostasis of mesenchymal stem cells

Liangjing Xin; Yao Wen; Jinlin Song; Tao Chen; Qiming Zhai

doi:10.3389/fendo.2023.1151691

Bone regeneration strategies based on organelle homeostasis of mesenchymal stem cells

Front Endocrinol (Lausanne). 2023 Mar 17:14:1151691. doi: 10.3389/fendo.2023.1151691. eCollection 2023.

Authors

Liangjing Xin^{1

2}, Yao Wen^{1

2}, Jinlin Song^{1

2}, Tao Chen^{1

2}, Qiming Zhai^{1

2}

Affiliations

¹ College of Stomatology, Chongqing Medical University, Chongqing, China.
² Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.

Abstract

The organelle modulation has emerged as a crucial contributor to the organismal homeostasis. The mesenchymal stem cells (MSCs), with their putative functions in maintaining the regeneration ability of adult tissues, have been identified as a major driver to underlie skeletal health. Bone is a structural and endocrine organ, in which the organelle regulation on mesenchymal stem cells (MSCs) function has most been discovered recently. Furthermore, potential treatments to control bone regeneration are developing using organelle-targeted techniques based on manipulating MSCs osteogenesis. In this review, we summarize the most current understanding of organelle regulation on MSCs in bone homeostasis, and to outline mechanistic insights as well as organelle-targeted approaches for accelerated bone regeneration.

Keywords: mesenchymal stem cells; organelle regulation; osteogenesis; subcellular homeostasis; target strategies.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Bone Regeneration*
Bone and Bones
Mesenchymal Stem Cells*
Organelles
Osteogenesis

Grants and funding

This work was supported by the National Natural Science Foundation of China (82201059, 32071362), the Chongqing Post-doctoral Science Special Foundation (2021XM1031), the Natural Science Foundation of Chongqing, China (2022NSCQ-BHX0033).