Compliance with enhanced recovery after surgery predicts long-term outcome after hepatectomy for cholangiocarcinoma

Chaowasaporn Jongkatkorn; Vor Luvira; Chalisa Suwanprinya; Kantaruthai Piampatipan; Natwutpong Leeratanakachorn; Theerawee Tipwaratorn; Attapol Titapun; Tharatip Srisuk; Suapa Theeragul; Apiwat Jarearnrat; Vasin Thanasukarn; Ake Pugkhem; Narong Khuntikeo; Chawalit Pairojkul; Supot Kamsa-Ard; Vajarabhongsa Bhudhisawasdi

doi:10.4240/wjgs.v15.i3.362

Compliance with enhanced recovery after surgery predicts long-term outcome after hepatectomy for cholangiocarcinoma

World J Gastrointest Surg. 2023 Mar 27;15(3):362-373. doi: 10.4240/wjgs.v15.i3.362.

Authors

Chaowasaporn Jongkatkorn¹, Vor Luvira², Chalisa Suwanprinya¹, Kantaruthai Piampatipan¹, Natwutpong Leeratanakachorn³, Theerawee Tipwaratorn¹, Attapol Titapun¹, Tharatip Srisuk¹, Suapa Theeragul¹, Apiwat Jarearnrat¹, Vasin Thanasukarn¹, Ake Pugkhem¹, Narong Khuntikeo¹, Chawalit Pairojkul⁴, Supot Kamsa-Ard⁵, Vajarabhongsa Bhudhisawasdi¹

Affiliations

¹ Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
² Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. vor_110@yahoo.com.
³ Department of Surgery, Saraburi Hospital, Saraburi 18000, Thailand.
⁴ Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
⁵ Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen 40002, Thailand.

Abstract

Background: Enhanced recovery after surgery (ERAS) program has been proved to improve postoperative outcome for many surgical procedures, including liver resection. There was limited evidence regarding the feasibility and benefit of ERAS in patients who underwent liver resection for cholangiocarcinoma.

Aim: To evaluate the feasibility of ERAS in patients who underwent liver resection for cholangiocarcinoma and its association with patient outcomes.

Methods: We retrospectively analyzed 116 cholangiocarcinoma patients who underwent hepatectomy at Srinagarind Hospital, Khon Kaen University between January 2015 and December 2016. The primary outcome was the compliance with ERAS. To determine the association between ERAS compliance and patient outcomes. the patients were categorized into those adhering more than and equal to 50% (ERAS ≥ 50), and below 50% (ERAS < 50) of all components. Details on type of surgical procedure, preoperative and postoperative care, tumor location, postoperative laboratory results, and survival time were evaluated. The compliance with ERAS was measured by the percentage of ERAS items achieved. The Kaplan-Meier curve was used for survival analysis.

Results: The median percentage of ERAS goals achieved was 40% (± 12%). Fourteen patients (12.1%) were categorized into the ERAS ≥ 50 group, and 102 patients were in the ERAS < 50 group. Postoperative hospital stay was significantly shorter in the ERAS ≥ 50 group [8.9 d, 95% confidence interval (CI): 7.3-10.4 d] than in the ERAS < 50 group (13.7 d, 95%CI: 12.2-15.2 d) (P = 0.0217). No hepatobiliary-related complications or in-hospital mortality occurred in the ERAS ≥ 50 group. Overall survival was significantly higher in the ERAS ≥ 50 group. The median survival of the patients in the ERAS < 50 group was 1257 d (95%CI: 853.2-1660.8 d), whereas that of the patients in the ERAS ≥ 50 group was not reached.

Conclusion: Overall ERAS compliance for patients who underwent liver resection for cholangiocarcinoma is poor. Greater ERAS compliance could predict in-hospital, short-term, and long-term outcomes of the patients.

Keywords: Cholangiocarcinoma; Enhanced recovery after surgery; Enhanced recovery program after surgery; Hepatectomy; Outcome; Survival.