Comparison of Al 18F-NOTA-FAPI-04 and 18F-FDG in recurrent esophageal cancer after surgery

Wei Zhang; Wei Diao; Zhuzhong Cheng

doi:10.1967/s002449912559

Comparison of Al ¹⁸F-NOTA-FAPI-04 and ¹⁸F-FDG in recurrent esophageal cancer after surgery

Hell J Nucl Med. 2023 Jan-Apr;26(1):75-77. doi: 10.1967/s002449912559. Epub 2023 Apr 11.

Authors

Wei Zhang¹, Wei Diao, Zhuzhong Cheng

Affiliation

¹ Department of Nuclear Medicine, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China. zhuzhongcheng@yeah.net.

PMID: 37031426
DOI: 10.1967/s002449912559

Abstract

Recently, radionuclide labelling fibroblast activating protein inhibitors (FAPI) is regarded as the most promising imaging tracer forvarious tumours. Here we present the imaging finding of aluminium-[¹⁸F] fluoride (Al¹⁸F)-labelled 1,4,7-triazacyclononane-N,N',N"-triacetic acid (Al¹⁸F-NOTA-FAPI-04) and fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) in postoperative recurrence esophageal cancer. The results presented that imaging with Al¹⁸F-NOTA-FAPI-04 showed significant improvement in detection of local recurrence and distant metastasis with higher maximum standardized uptake value (SUVmax) in the lesions compared with ¹⁸F-FDG.

MeSH terms

Esophageal Neoplasms* / diagnostic imaging
Esophageal Neoplasms* / surgery
Fibroblasts
Fluorodeoxyglucose F18
Gallium Radioisotopes
Humans
Neoplasm Recurrence, Local / diagnostic imaging
Positron Emission Tomography Computed Tomography
Quinolines*

Substances

Fluorodeoxyglucose F18
1,4,7-triazacyclononane-N,N',N''-triacetic acid
68Ga-FAPI
Gallium Radioisotopes
Quinolines