The associations between cognitive functions and TSNAX genetic variations in patients with schizophrenia

Kuan-Yu Huang; Yu-Jhen Huang; Shaw-Ji Chen; Chieh-Hsin Lin; Hsien-Yuan Lane

doi:10.1016/j.pbb.2023.173554

The associations between cognitive functions and TSNAX genetic variations in patients with schizophrenia

Pharmacol Biochem Behav. 2023 Apr:225:173554. doi: 10.1016/j.pbb.2023.173554. Epub 2023 Apr 7.

Authors

Kuan-Yu Huang¹, Yu-Jhen Huang¹, Shaw-Ji Chen², Chieh-Hsin Lin³, Hsien-Yuan Lane⁴

Affiliations

¹ Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan.
² Department of Psychiatry, Mackay Memorial Hospital Taitung Branch, Taitung 950408, Taiwan; Department of Medicine, Mackay Medical College, New Taipei 25245, Taiwan.
³ Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan; Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan; School of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. Electronic address: cyndi36@gmail.com.
⁴ Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan; Department of Psychiatry & Brain Disease Research Center, China Medical University Hospital, Taichung 404332, Taiwan; Department of Psychology, College of Medical and Health Sciences, Asia University, Taichung 413305, Taiwan. Electronic address: hylane@gmail.com.

PMID: 37030547
DOI: 10.1016/j.pbb.2023.173554

Abstract

Background: The translin-associated factor X (TSNAX) gene, located adjacent to the DISC1 gene, has been implicated in schizophrenia. While cognitive impairment determines long-term the functional outcome of schizophrenia, the role of TSNAX in cognitive dysfunction of schizophrenia patients remains elusive. This study aimed to explore the genetic effect of TSNAX on cognitive functions of schizophrenia.

Methods: We recruited 286 chronic schizophrenia patients who had been stabilized with antipsychotics for at least 2 months and genotyped three TSNAX SNPs (rs1630250, rs766288, rs6662926). Clinical symptoms and seven cognitive domains were assessed. The score of cognitive tests was standardized to T score.

Results: Clinical symptoms were similar among genotypes of all the three SNPs. The GLM analysis demonstrated that TSNAX genetic polymorphisms influenced cognitive function of schizophrenia patients after adjustment for gender, age, and education. The patients with the rs1630250 C/G genotype performed better than the G/G homozygotes in the Trail Making A (p = 0.034). Those with the rs766288 G/T genotype also performed better than the G/G homozygotes in the Trail Making A (p = 0.012). The patients with the G/G genotype of rs6662926 also performed better than the C/C homozygotes in verbal learning and memory test (p = 0.044).

Conclusions: This study suggests that the TSNAX gene variation may influence the cognitive functions of the patients with schizophrenia.

Keywords: Cognitive functions; Genetic variations; Schizophrenia; Single nucleotide polymorphism; TSNAX.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cognition
Cognitive Dysfunction* / genetics
Genotype
Humans
Polymorphism, Single Nucleotide
Schizophrenia* / drug therapy
Schizophrenia* / genetics