Myeloid sarcoma in a newborn: A rare manifestation of congenital acute myeloid leukemia

Brooke Mullen; Kazuhiro Sabet; Shana Jacobs; Amanda Theresa Calleroz; Kaiane Anoush Habeshian; Jinjun Cheng

doi:10.1111/pde.15313

Myeloid sarcoma in a newborn: A rare manifestation of congenital acute myeloid leukemia

Pediatr Dermatol. 2023 Jul-Aug;40(4):751-752. doi: 10.1111/pde.15313. Epub 2023 Apr 7.

Authors

Brooke Mullen¹, Kazuhiro Sabet², Shana Jacobs², Amanda Theresa Calleroz³, Kaiane Anoush Habeshian⁴, Jinjun Cheng³

Affiliations

¹ Departments of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, Virginia, USA.
² Department of Hematology and Oncology, Children's National Hospital, Washington, DC, USA.
³ Department of Pathology and Laboratory Medicine, Children's National Hospital, Washington, DC, USA.
⁴ Division of Dermatology, Children's National Hospital, Washington, DC, USA.

PMID: 37029447
DOI: 10.1111/pde.15313

Abstract

Cutaneous myeloid sarcoma is rarely present prior to the diagnosis of congenital acute myeloid leukemia (AML); the former is typically diagnosed with or after the leukemia. We report a 2-day-old male born with multiple cutaneous red to violaceous nodules. Histopathologic and immunohistochemistry findings from a skin nodule were suspicious for myeloid sarcoma. Bone marrow biopsy was initially negative for aberrant blasts; however, at age 4 months, AML with a KMT2A gene rearrangement was identified via bone marrow biopsy.

Keywords: KMT2A; congenital acute myeloid leukemia; myeloid sarcoma.

Publication types

Case Reports

MeSH terms

Bone Marrow / pathology
Humans
Infant
Infant, Newborn
Leukemia, Myeloid, Acute* / diagnosis
Leukemia, Myeloid, Acute* / genetics
Leukemia, Myeloid, Acute* / pathology
Male
Sarcoma, Myeloid* / diagnosis
Sarcoma, Myeloid* / genetics
Sarcoma, Myeloid* / pathology
Skin / pathology
Skin Neoplasms* / pathology