Mycoplasma infection mimicking a malignancy in a waldenstrom macroglobulinemia patient

Junqing Wu; Donghua He; Fang Yu; Yue Huang; Meiru Bian; Chengxuan Yu; Jiao Liu; Zhen Cai; Yi Zhao

doi:10.1186/s12879-023-08163-6

Mycoplasma infection mimicking a malignancy in a waldenstrom macroglobulinemia patient

BMC Infect Dis. 2023 Apr 7;23(1):219. doi: 10.1186/s12879-023-08163-6.

Authors

Junqing Wu^{1

2}, Donghua He^{1

2}, Fang Yu³, Yue Huang¹, Meiru Bian⁴, Chengxuan Yu⁵, Jiao Liu⁶, Zhen Cai^{1

2

7

8}, Yi Zhao^{9

10}

Affiliations

¹ Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China.
² Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 310000, China.
³ Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China.
⁴ Department of Hematology, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huaian, 223001, China.
⁵ Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, The Second Affiliated Hospital, Ministry of Education, Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, China.
⁶ Hangzhou Xixi Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310000, Zhejiang, China.
⁷ Institute of Hematology, Zhejiang University, Hangzhou, 310000, Zhejiang, China.
⁸ Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, 310000, China.
⁹ Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China. zhaoyi999@zju.edu.cn.
¹⁰ Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 310000, China. zhaoyi999@zju.edu.cn.

Abstract

Background: Mycoplasma hominis infection is common in urinary tract. ¹⁸F-FDG-PET/CT is a valuable tool for tumor and infection diagnosis. Few studies have shown the ¹⁸F-FDG-PET/CT images after mycoplasma infection.

Case presentation: Here we described a case of Waldenstrom macroglobulinemia with thickened bladder wall. The ¹⁸F-FDG-PET/CT showed the SUVmax up to 36.1 mimicking bladder cancer. The results of histopathological examination and metagenomic sequencing of the blood and urinary revealed the Mycoplasma hominis infection.

Conclusion: The full consideration should be given to the possibility of infection besides tumor in lesions with high SUV value in ¹⁸F-FDG-PET/CT, especially in immunodeficiency patients.

Keywords: 18F-FDG-PET/CT; Bladder cancer; Mycoplasma hominis; Waldenstrom macroglobulinemia.

Publication types

Case Reports

MeSH terms

Diagnosis, Differential
Fluorodeoxyglucose F18
Humans
Neoplasms
Positron Emission Tomography Computed Tomography / methods
Positron-Emission Tomography
Radiopharmaceuticals
Urinary Bladder Neoplasms*
Waldenstrom Macroglobulinemia* / diagnosis

Substances

Fluorodeoxyglucose F18
Radiopharmaceuticals

Abstract

Publication types

MeSH terms

Substances

Grants and funding