The expression of Runx2 in the pathogenesis of periodontitis

Miaomiao Wang; Chunjiao Xu; Xiaoshan Wu; Xiufang He; Yiting Guo; Wenrui Zhang; Yumei Sun

doi:10.1111/odi.14580

The expression of Runx2 in the pathogenesis of periodontitis

Oral Dis. 2023 Apr 7. doi: 10.1111/odi.14580. Online ahead of print.

Authors

Miaomiao Wang^{1

2}, Chunjiao Xu^{1

3}, Xiaoshan Wu^{4

5}, Xiufang He¹, Yiting Guo¹, Wenrui Zhang¹, Yumei Sun¹

Affiliations

¹ Department of Periodontology, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China.
² Department of Periodontology, Shanghai Xuhui District Dental Center, Shanghai, China.
³ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China.
⁴ Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China.
⁵ Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China.

PMID: 37026687
DOI: 10.1111/odi.14580

Abstract

Objective: Runt-related transcription factor 2 (Runx2) plays an important role in bone metabolism; however, the relationship between Runx2 and periodontitis remains unclear. We investigated Runx2 expression in the gingiva of patients to explore its role in periodontitis.

Methods: Gingival samples of patients were collected, including healthy samples (control group) and periodontitis samples (P group). Periodontitis samples were divided into three groups based on the periodontitis stage. Samples with stage I and grade B periodontitis were in the P1 group, stage II and grade B in the P2 group, and stage III or IV and grade B in the P3 group. Immunohistochemistry and western blotting were performed to detect Runx2 levels. The probing (PD) and clinical attachment loss (CAL) were recorded.

Results: Runx2 expression levels in the P and P3 groups were higher than those in the control group. In addition, Runx2 expression was positively correlated with CAL and PD (r1 = 0.435, r2 = 0.396).

Conclusion: The high expression level of Runx2 in the gingiva of patients with periodontitis may be correlated with the pathogenesis of periodontitis.

Keywords: Runx2; gingiva; periodontitis.

Abstract

Grants and funding